Biology Department Faculty
Kenneth C. Williams
Professor
Kenneth C. Williams
Ph.D.
Contact
Higgins Hall 468
Telephone: 617-552-1186
Email: kenneth.williams.3@bc.edu
Education
- Ph.D., McGill University
Research Interests
Central nervous system macrophages, neuroAIDS, AIDS pathogenesis, monocyte/macrophage biology.
Department
Research
My laboratory's major research activity centers on CNS inflammation and normal and diseased states. Specifically, we focus on the role of CNS macrophages and CD8 T lymphocytes in pathogenesis of lentiviral infection. This work includes: a) studies to define subpopulations of macrophages in the CNS and their precursors in blood and bone marrow, b) the role of the cellular immune system especially CD8 T cells controlling monocyte/macrophage activation and CNS pathogenesis, and c) developing drugs that target HIV and SIV infected/activated macrophages resulting in cell death or deactivation. In addition, we are exploring an exciting field of emergent populations of monocytes and dendritic cells that are expanded with disease. This work uses a monkey model of rapid, consistent AIDS and neuroAIDS, CD8 T lymphocyte depletion, MR spectroscopy, monocyte/macrophage biology and immunology.
Selected Publications
- Fitch KV,聽Srinivasa S,聽Abbara S,聽Burdo TH,聽Williams KC,聽Eneh P,聽Lo J,聽Grinspoon SK. , J Infect Dis.聽2013 Sep 16. (Epub ahead of print).
- Burdo TH, Lackner A and Williams KC, , Immunological Reviews, 2013 Jul; 254(1):102-13.
- Burdo TH, Weiffenbach A, Woods SP, Letendre S, Ellis RJ and Williams KC, , AIDS. 2013 Jun 1;27(9):1387-95.
- Pereyra F, Lo J, Triant VA, Wei J, Buzon MJ, Fitch KV, Hwang J, Campbell JH, Burdo TH, Williams KC, Abbara S, Grinspoon SK. . AIDS. 2012 Nov 28;26(18):2409-12.
- Subramanian S, Tawakol A, Burdo TH, Abbara S, Wei J, Vijayakumar J, Corsini E, Abdelbaky A, Zanni MV, Hoffmann U, Williams KC, Lo J, Grinspoon SK. . JAMA. 2012 Jul 25;308(4):379-86. With Editorial Commentary. PMID: 22820791
- Strickland SL, Gray RR, Lamers S, Burdo TH, Huenink E, Nolan D, Nowlin B, Alvarez X, Midkiff C, Goodenow M, Williams K, Salemi M. . J Gen Virol May 2012 93 (Pt 5):925-938 PMID: 22302881
- Burdo TH, Orzechowski K, Knight HL, Miller AD, Williams KC. Am J Pathol. 2012 Apr;180(4):1362-9. PMID: 22322298
- Williams K and Burdo TH. . Journal of Neuroimmune Pharmacol. 2012 Jun;7(2):363-71. PMID: 22167311
- Williams K, Hickey WF, Burdo TH and Soulas C. . In: The Neurology of AIDS. HE Gendelman, I Grant, IP Everall, HS Fox, HA Gelbard, SA Lipton, S Swindells (eds). 2012 Chapman and Hall, New York, NY.
- Zanni MV*, Burdo TH*, Makimura H, Williams KC, Grinspoon S. . Clinical Endocrinology, accepted October 31, 2011. *Authors contributed equally.
- Burdo TH, Lo J, Abbara S, Wei J, Delelys ME, Preffer F, Rosenberg ES, Williams KC, Grinspoon S. . J Infect Dis. 2011 Oct;204(8):1227-36.
- Strickland S, Gray R, Lamers SL, Burdo TH, Huenink E, Nolan DJ, Nowlin B, Alvarez A, Midkiff CC, Goodenow MM, Williams K, Salemi M. . AIDS Research and Human Retoviruses, Apr 27. [Epub ahead of print].
- Burdo TH, Lentz MR, Autissier P, Krishnan A, Halpern E, Letendre S, Rosenberg ES, Ellis RJ and Williams KC. . Journal of Infectious Diseases, Jul;204(1):154-63.
- Soulas C, Conerly-Midiff C, Kim W-K, Burdo TH, Alaverz A, Lackner A, Williams KC. , American Journal of Pathology, 2011 May;178(5):2121-35. PMID: 21514427.
- Campbell JH, Burdo TH, Autissier P, Bombardier JP, Westmoreland SV, Soulas C, Gonz谩lez RG, Ratai E-M, Williams KC, , PLoS One. 2011 April 6.
- Ratai E-M, Pilkenton S, He J, Fell R, Bombardier JP, Joo C-G, Lentz MR, Kim W-K, Burdo TH, Autissier P, Annamalai L, Curran E, O鈥橬eil S, Westmoreland SV, Williams KC, Masliah E, Gonz谩lez RG , J Med Primatol. 2011 Apr 4. doi: 10.1111/j.1600-0684.2011.00475.x. [Epub ahead of print].
- Ratai E-M, Annamalai L, Burdo TH, Joo CG, Bombardier JP, Fell R, Hakimelahi R, He J, Lentz MR, Campbell J, Curran E, Halpern EF, Masliah E, Westmoreland SV, Williams KC, Gonz谩lez RG, . Magn Reson Med. 2011 Mar 4. doi: 10.1002/mrm.22821. [Epub ahead of print]
- Autissier, P., Soulas, C., Burdo, T., Williams, K. 2010. . Journal of Immunological Methods (in press).
- Raitai, E., Bombardier, J., Joo, C.-G., Annamalai, L., Burdo, T., Campbell, J., Fell, R., Hakimelahi, R., He, J., Autissier, P., Lentz, M., Halpern, E., Masliah, E., Williams, K., Westmoreland, S., Gonzalez, R.G. 2010. . PloS ONE 5(5): e10523, doi:10.1371/journal.pone.0010523.
- Burdo, T., Soulas, C., Orzechowski, K., Button, J., Krishnan, A., Sugimoto, C., Alvarez, X., Kuroda, M., and Williams, K. 2010. . PloS Pathogens 6(4): e1000842.
- Autisseri, P., Soulas, C., Burdo, T.H., and Williams, K. 2010. . Cytometry A: Jan. 22, 2010 [Epub ahead of print].